Capitulo 1 – Download as PDF File .pdf), Text File .txt) or read online. Introducao-Bioestatística – Uploaded by. by Deborah Rumsey and if you can read in portuguese: Introdução a Bioestatística para simples mortais, by Ulysses Doria Filho) and take my. . -assassinos-e-poetas-que-sonharam-a-independencia-do-brasil-pedro-doria .

Author: Taurg Shakazragore
Country: Azerbaijan
Language: English (Spanish)
Genre: Automotive
Published (Last): 12 July 2005
Pages: 114
PDF File Size: 2.63 Mb
ePub File Size: 17.34 Mb
ISBN: 750-5-98376-444-8
Downloads: 49272
Price: Free* [*Free Regsitration Required]
Uploader: Akikus

Data and results Patients in the validated polymyxin combination therapy had more severe infections and more serious disease, monotherapy group was older. Here we have a problem, Immortal Time Bias.

S Army — Delta associates — Memegenerator. Patients were included if: The ART trial and how lung recruitment died. All these information makes me wonder about the results of the multivariate analysis. Recently I did a review of literature about combination therapy for multi-drug resistant bacterias and soon you will see here.

The primary outcome was infection related mortality, which was determined by the attending physician another bias here. Keep this in mind! Combination therapy for non-believers, and believers too! To begin with, I can do an observational trial, either retrospective or prospective, showing that doctors who drink wine 7 days a week have more sex.

Moving on… The eligible patients were divided in three groups: The only group which received polymyxin at adequate dose was the VCT group. One interesting fact is that even with lot of difference among polymyxin doses no difference in nephropathy RIFLE was showed. Meaning, if you wanna treat them, do it with the right dose! The median of adequate treatment for monotherapy group was ZERO! I agree that is not easy to study the same bacteria, for example, Klebsiella pneumoniae carbapenemase Gen2.


Patients in the validated polymyxin combination therapy had more severe infections and more serious disease, monotherapy group was older.

Now, to study Klebsiella pneumoniae carbapenemase Gen2 causing blood stream infection and compare between monotherapy vs combined therapy? Another thing is to realize that the study compares different sites of infection doira different bacterias.

There it is, nebulized and intravenous are the same? Is the HCAP concept a lie?

Filgo after a multivariate analysis the authors throw the results saying the risk of infection related mortality is 8x greater in MT group and 6x greater in NVCT group when compared to VCT group. In their majority, the most cited, are observational trials. For me the idea of using lower doses to avoid adverse affects might increase bacterial resistance.

From a statistical point of view, the drinker only begin to exist at day So, if I begin with polimyxin and just after 3 days inteoduo amikacin, this guy who recive amikacin is the same that our 5th day drunk guy.

Combination therapy for non-believers, and believers too!

Why I hate tramadol but sometimes use it. This was a unicentric, retrospective study that from evaluated antibiotic combinations to guide therapy in patients with extensively drug-resistant gram negative bacilli XDR GNB infections of any site. Because he had to survive our attempts to kill him as intensivists until day 5.


If you do agree, read the literature we have available today about combination therapy. Interestingly, was considered polymyxin use any of: Is that honest to fjlho this group with others?

Even if the patients in the VCT group were more sick, it was the only group which received adequate dose treatment.

Take another look at the antibiotics doses table. This is gonna be a bioestatietica theme here, so keep your eyes open! Nothing but the whole truth.

Combination therapy for non-believers, and believers too! – ICU Revisited

Go hit the books then. The antibiotic dose was included in the multivariate model. Therefore, if you read an article showing a possible association between combined therapy and lower mortality and take this as true I can recommend you two books Statistics for Dummies, by Deborah Rumsey and if you can read in portuguese: Therefore, beer drinkers have lower mortality than sober patients.

Both groups with combined therapy had more infections caused by Klebsiella pneumoniae and Pseudomonas aeruginosas when the monotherapy group more Acinetobacter baumannii infections. And also other strange things happened. I can show you that a intfoduo who drinks beer at 5th day of ICU have lower mortality than a patient who does not.