FORMULASI SUSPENSION PDF

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Keywords: Dry suspension, Taste Masking, Macrolide Antibiotic, Eudragit L . formula F = Vu/Vo, where Vu is the volume of sediment and Vo. Route Dosage Form. Concentration. Sulfamethoxazole-Trimethoprim Oral Suspension 40mg/5mL. Formula Qty: mL. Shelf Life: 20 days. Hospital Of Eastern Ontario. MASTER FORMULA SHEET – NON-STERILE MANUFACTURING. PRODUCT: PROPRANOLOL 5 mg/mL ORAL SUSPENSION .

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Designed cefuroxime axetil formulations had good qualities and could be added as a new product to Iran drug marketing. A sample of these curves is shown in Figure 2.

Considering no sedimentation, the sedimentation volume was determined to be 1. Other tests, including measurement of pH, viscosity and zeta potential measurements were performed and finally the best formulations were selected. From all 33 formulations, only suspwnsion were selected to further investigation.

Cefuroxime is the second generation cephalosporin, which its intravenous and oral dosage forms are available. Results From all 33 formulations designed in Minitab software, only 9 was selected to further investigation that are listed in the Table 1. A new approach to HPLC analysis of medicinal suspensions. Open in a separate window. Then using equation derived from calibration curve. According to the obtained results and considering the ideal characteristics of prepared suspension formulations, this product can be added to drug market.

Since cefuroxime is not absorbed orally, the 1-acetyloxyethyl axetil ester of cefuroxime was used to improve its gastrointestinal absorption. Evaluation of physical stability Made formulations are then evaluated for physical stability tests in which the sedimentation volume the ratio of the final volume of the sediment to the flrmulasi volume of the suspension and degree of flocculation the ratio of the ultimate sediment volume of flocculated suspension to the ultimate sediment volume of deflocculated suspension were conducted.

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Formulation of cefuroxime axetil oral suspension and investigation of its pharmaceutical properties

Author information Article notes Copyright and License information Disclaimer. Eur J Pharm Sci. Influence of the soluble solids on the zeta potential of the cloudy apple juice. All other chemicals were purchased fromMerck, Darmstadt, Germany.

According to these properties a general discussion is presented. Eur J Pharm Biopharm. After calculating the viscosity, the curves of viscosity against shear rate were plotted. An advantage of cefuroxime over other second-generation cephalosporins is that it is effective in the treatment of Neisseria gonorrhea and H influenzae. Table 1 Composition of selected formulations designed in Minitab ver.

The charge of the particles effects their distribution in the environment and increases the concentration of opposite charge on the surface close to them which produces electric double layer. A sample viscosity curve for formulated suspension. Bioequivalence evaluation of two brands of cefuroxime mg tablets cefuzime and zinnat in healthy volunteers. Pharmacokinetic models for the saturable absorption of cefuroxime axetil and saturable elimination of cefuroxime axetil.

For suspension formulation equivalent to mg of cefuroxime was suspended in 5 ml vehicle, after selecting the type and concentration of wetting agent, other ingredients such as flocculating agents, suspending agents, preservatives and flavors were added. Published online Dec Tabibi S, Rhodes CH. Martin’s Physical Pharmacy and Pharmaceutical Sciences. This article has been cited by other articles in PMC.

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Made formulations are then evaluated for physical stability tests in which the sedimentation volume the ratio of the final volume of the sediment to the original volume of the suspension and degree of flocculation the ratio of the ultimate sediment volume of flocculated suspension to the ultimate sediment volume of deflocculated suspension were conducted. Table 2 Results of assay test. Also the system was found to be time-depended. Formulation of suspensions One of the methods for making the suspension, is the dispersion of a particle in a vehicle that can be done by mechanical instruments or by the use of surfactants that contains three steps: For 3 of each formulation, dissolution test was performed with USP 2 apparatus Paddle in 50 rpm for 30 minutes.

Formulation of cefuroxime axetil oral suspension and investigation of its pharmaceutical properties

Remington the science and practice of Pharmacy. Percentage of release for all selected formulations.

Acknowledgement The authors would like to thank Dana Pharmaceutical Co.